170

Huerta-Cepas J, Forslund K, Coelho LP, Szklarczyk D, Jensen LJ, von Mering C, Bork P (2017)

Fast genome-wide functional annotation through orthology assignment by eggNOG-Mapper.

Mol Biol Evol 34(8):2115–2122

Khan AI, Dinh DM, Schneider D et al (2011) Negative epistasis between beneficial mutations in

an evolving bacterial population. Science 332(6034):1193–1196. https://doi.org/10.1126/sci­

ence.1203801. (PubMed PMID: 21636772)

Letunic I, Doerks T, Bork P (2015 Jan) SMART: recent updates, new developments and status in

2015. Nucleic Acids Res 43(Database issue):D257–D260

Lu S, Wang J, Chitsaz F, Derbyshire MK, Geer RC, Gonzales NR, Gwadz M, Hurwitz DI, Marchler

GH, Song JS, Thanki N, Yamashita RA, Yang M, Zhang D, Zheng C, Lanczycki CJ, Marchler-

Bauer A (2020) CDD/SPARCLE: the conserved domain database in 2020. Nucleic Acids Res

48(D1):D265–D268

McKie D (1944) Wöhler’s synthetic urea and the rejection of vitalism: a chemical Legend. Nature

152:608–610

Nelson KE, Levy M, Miller SL (2000) Peptide nucleic acids rather than RNA may have been the first

genetic molecule. Proc Natl Acad Sci USA 97(8):3868–3871

Nielsen PE, Egholm M, Berg RH et al (1991) Sequence-selective recognition of DNA by strand

displacement with a thymine-substituted polyamide. Science 254(5037):1497–1500. https://doi.

org/10.1126/science.1962210. (PMID: 1962210)

Weiss MC, Preiner M, Xavier JC, Zimorski V, Martin WF (2018) The last universal common ances­

tor between ancient Earth chemistry and the onset of genetics. PLoS Genet 14(8):e1007518.

https://doi.org/10.1371/journal.pgen.1007518

12  Life Continuously Acquires New Information in Dialogue with the Environment